Analyses of linkage to 17q11-q23 in 3 French hereditary nonpolyposis colon-cancer families. - Institut Curie Accéder directement au contenu
Article Dans Une Revue International Journal of Oncology Année : 1995

Analyses of linkage to 17q11-q23 in 3 French hereditary nonpolyposis colon-cancer families.

Résumé

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, accounting for approximately 6% of colorectal cancers. We performed linkage analyses with the aim of proving or excluding the existence of a susceptibility locus on 17q. Three HNPCC families (102 collected members, 25 colorectal cancers, 9 other cancers and 6 colorectal adenomas) were studied with 7 polymorphic DNA markers Mfd15, THRA 1, D17S800, D17S855, Mfd 188, 42D6, 46E6 localized in the 17q11-q23 region. After in vitro enzymatic amplification, the different alleles were separated by classic vertical poly-acrylamide gel electrophoresis or analyzed with the automatic sequencing machine 373A (Applied Biosystems). Results showed that none of the 7 studied markers of the chromosome 17q were linked to the HNPCC disease.
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Dates et versions

hal-01981150 , version 1 (14-01-2019)

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Dominique Bernard-Gallon, Sandrine Gosse, Laurent Essioux, Pierre Laurent-Puig, Cécile Ralliere, et al.. Analyses of linkage to 17q11-q23 in 3 French hereditary nonpolyposis colon-cancer families.. International Journal of Oncology, 1995, 6 (3), pp.693-697. ⟨10.3892/ijo.6.3.693 ⟩. ⟨hal-01981150⟩
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