Aneuploidy causes premature differentiation of neural and intestinal stem cells - Institut Curie Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2015

Aneuploidy causes premature differentiation of neural and intestinal stem cells

Katarzyna Siudeja
  • Fonction : Auteur
Davide Gambarotto
  • Fonction : Auteur
Carole Pennetier
  • Fonction : Auteur
Allison J Bardin
Renata Basto

Résumé

Aneuploidy is associated with a variety of diseases such as cancer and microcephaly. Although many studies have addressed the consequences of a non-euploid genome in cells, little is known about their overall consequences in tissue and organism development. Here we use two different mutant conditions to address the consequences of aneuploidy during tissue development and homeostasis in Drosophila. We show that aneuploidy causes brain size reduction due to a decrease in the number of proliferative neural stem cells (NSCs), but not through apoptosis. Instead, aneuploid NSCs present an extended G1 phase, which leads to cell cycle exit and premature differentiation. Moreover, we show that this response to aneuploidy is also present in adult intestinal stem cells but not in the wing disc. Our work highlights a neural and intestine stem cell-specific response to aneuploidy, which prevents their proliferation and expansion.
Fichier principal
Vignette du fichier
ncomms9894.pdf (5.08 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03455120 , version 1 (29-11-2021)

Identifiants

Citer

Delphine Gogendeau, Katarzyna Siudeja, Davide Gambarotto, Carole Pennetier, Allison J Bardin, et al.. Aneuploidy causes premature differentiation of neural and intestinal stem cells. Nature Communications, 2015, 6, ⟨10.1038/ncomms9894⟩. ⟨hal-03455120⟩

Collections

FNCLCC CURIE FRM
6 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More