IgE Ratio in Tears: A Predictive Tool of Ocular Allergic Inflammation - Plateforme Cytométrie Accéder directement au contenu
Article Dans Une Revue Ocular Immunology and Inflammation Année : 2019

IgE Ratio in Tears: A Predictive Tool of Ocular Allergic Inflammation

Résumé

To demonstrate the tear IgE (measured/exuded) ratio (R) as a useful biological marker of ocular allergy in order to distinguish severe from less severe inflammatory status. Methods: Tear samples and sera from 78 ocular allergy patients and 19 control subjects were analyzed. Total IgE and albumin were measured for calculating the tear IgE-R defining two subgroups (SG) of samples: R ≥ 4-SG and R < 4-SG. Eosinophil cationic protein, Th1 and Th2 cytokines (IFN-γ, IL-4, -5, -6, -8 and -10) and protein electrophoretic profiles were also investigated in tears. Results: The R < 4-SG compared to the R ≥ 4-SG shows higher levels of tear albumin, eosinophil cationic protein, and Th1 and Th2 cytokines. Moreover, each subgroup presents a specific protein profile. Conclusion: This study showed that an IgE-R lower than four must be carefully interpreted as a warning sign of a severe inflammatory context and should be also associated with an exploration of immunological profile.
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Dates et versions

hal-02613711 , version 1 (20-05-2020)

Identifiants

  • HAL Id : hal-02613711 , version 1
  • PUBMED : 31411517

Citer

Jean Neil, K Kessal, L Merabet, A Kobal, S Bouhadiba, et al.. IgE Ratio in Tears: A Predictive Tool of Ocular Allergic Inflammation. Ocular Immunology and Inflammation, 2019. ⟨hal-02613711⟩
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