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Article Dans Une Revue Fertility and Sterility Année : 2021

Early identification of women with endometriosis by means of a simple patient-completed questionnaire screening tool: a diagnostic study

Résumé

Objectives: To assess the value of a self-completed questionnaire based on patients’ verbal descriptors of pelvic painful symptoms to identify women with endometriosis. Design: Prospective 1:2 nonmatched case-control study. Setting: Three French endometriosis referral centers. Patient(s): Endometriosis cases were women aged 18–45 years with endometriosis confirmed by histology. Controls were as follows: asymptomatic women attending a gynecologic consultation for routine examination; women without evidence of endometriosis consulting for pain/infertility; and population-based controls from the same urban locations. Intervention(s): All women completed the 21-item yes/no questionnaire about painful symptoms. Main Outcome Measure(s): The area under the receiver operating characteristic curve of the full question set model based on binary logistic regression and the diagnostic accuracy of low- and high-risk classification rules based on selected threshold of the prediction model. Result(s): We included 105 cases and 197 controls (45 asymptomatic consultation-based controls, 66 women without endometriosis consulting for pain/infertility, and 86 population-based controls). The full question set prediction model, including age, had an area under the receiver operating characteristic curve of 0.92 (95% confidence interval, 0.87–0.95) after internal validation. The high-risk classification rule had a specificity of 98.0% and a positive likelihood ratio of 30.5. The low-risk classification rule had a sensitivity of 98.1% and a negative likelihood ratio of 0.03. For a hypothesized pretest prevalence of 10%, the high- and low-risk prediction rules ascertained endometriosis with posttest probability rates of 77.2% and 0.3%, respectively. Conclusion(s): A self-completed patient-centered questionnaire can identify women at low or high risk of endometriosis with a high diagnostic accuracy and, thus, may help early identification of women with endometriosis.
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Origine : Publication financée par une institution

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hal-03487782 , version 1 (30-05-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Arnaud Fauconnier, Hocine Drioueche, Cyrille Huchon, Joseph Du Cheyron, Émilie Indersie, et al.. Early identification of women with endometriosis by means of a simple patient-completed questionnaire screening tool: a diagnostic study. Fertility and Sterility, 2021, 116 (6), pp.1580-1589. ⟨10.1016/j.fertnstert.2021.07.1205⟩. ⟨hal-03487782⟩
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