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Dernières publications
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
131
Publications avec texte intégral
Open Access
52 %
Mots clés
Astrocyte
Cytoskeleton
Myostatin
Exercice
Glutamate
Glial cells
Astrocytes
Neuron
Quantitative microdialysis
CTG repeat contractions
Myotonic dystrophy
Fibrosis
Motoneuron
Duchenne muscular dystrophy
Muscle
Hypoxia
Myelin
Intermediate filament
Central nervous system
Cardiac muscle
Dystrophie myotonique
Brain dysfunction
GSK3
In vivo
PCR
Trinucleotide repeat expansion
Exercise
Trinucleotide Repeat Expansion
Cell culture model
CTG repeats
GABA
Oligodendrocyte
Myotonic Dystrophy type 1
DMPK
Gene editing
Brain
Myotonic Dystrophy Type 1
Diaphragm
Transcriptomics
Dystrophin
Transgenic mouse
ARN
Heart
Cell model
Therapy
BIOLOGIE MOLECULAIRE
CMS
Myotonic dystrophy mouse models
Male
MBNL
Lc3
Acute coronary syndrome
Gene therapy
Centronuclear myopathy
Aging
Cell penetrating peptide
RNA biology
Acetylcholinesterase knockout mouse
Humans
Long read sequencing
AAV
RNA interference
Alternative splicing
Mice
RNA splicing
Acetylcholinesterase deficiency
Knockout
Myotonic dystrophy type 1
Desmin
Thérapie génique
Maximal force
DM1
Dynamin 2
Oligodendrocytes
Gene Therapy
CTG repeat instability
Mouse model
Animals
Expression
Antisense oligonucleotide
Skeletal muscle
Heart failure
PacBio
Antisense oligonucleotides
Glucocorticoid-receptor
Dilated cardiomyopathy
DMSXL mice
Myotonic Dystrophy
Genotype phenotype correlation
KNOCKOUT MICE
Autophagy
CRISPR/Cas9
ACETYLCHOLINESTERASE
Mouse models
Transgenic mouse model
CRISPRi
Muscular dystrophy
Glucocorticoids
CONGENITAL MYATHENIC SYNDROME
Dystrophie Myotonique